Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry
ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …
[HTML][HTML] Synthesis, molecular docking and ADMET studies of bis-benzimidazole-based thiadiazole derivatives as potent inhibitors, in vitro α-amylase and α …
Different research synthetic methods have been developed recently for the synthesis of bis-
benzimidazole analogs to investigate various biological significances. In this present study …
benzimidazole analogs to investigate various biological significances. In this present study …
Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors
S Moghadam Farid, M Noori, M Nazari Montazer… - Scientific Reports, 2023 - nature.com
In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed,
synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most …
synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most …
Chromone-based benzohydrazide derivatives as potential α-glucosidase inhibitor: Synthesis, biological evaluation and molecular docking study
M Fan, W Yang, Z Peng, Y He, G Wang - Bioorganic Chemistry, 2023 - Elsevier
In order to find new α-glucosidase inhibitors with high efficiency and low toxicity, novel
chromone-based benzohydrazide derivatives 6a-6s were synthesized and characterized …
chromone-based benzohydrazide derivatives 6a-6s were synthesized and characterized …
Cyanoacetohydrazide linked to 1, 2, 3-triazole derivatives: A new class of α-glucosidase inhibitors
A Iraji, D Shareghi-Brojeni, S Mojtabavi… - Scientific Reports, 2022 - nature.com
In this work, a novel series of cyanoacetohydrazide linked to 1, 2, 3-triazoles (9a–n) were
designed and synthesized to be evaluated for their anti-α-glucosidase activity, focusing on …
designed and synthesized to be evaluated for their anti-α-glucosidase activity, focusing on …
A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice
K Wang, L Bao, K Ma, J Zhang, B Chen, J Han… - European Journal of …, 2017 - Elsevier
Three new meroterpenoids, ganoleucin AC (1–3), together with five known meroterpenoids
(4–8), were isolated from the fruiting bodies of Ganoderma leucocontextum. The structures …
(4–8), were isolated from the fruiting bodies of Ganoderma leucocontextum. The structures …
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno [2, 3-b] quinoline-hydrazones as novel inhibitors for α-glucosidase
M Noori, M Rastak, M Halimi, MK Ghomi… - Bioorganic …, 2022 - Elsevier
In the development of novel anti-α-glucosidase agents, we synthesized novel thieno [2, 3-b]
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
Selenourea and thiourea derivatives of chiral and achiral enetetramines: Synthesis, characterization and enzyme inhibitory properties
A series of chiral and achiral cyclic seleno-and thiourea compounds bearing benzyl groups
on N-atoms were prepared from enetetramines and appropriate Group VI elements in good …
on N-atoms were prepared from enetetramines and appropriate Group VI elements in good …