The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

[HTML][HTML] On the origins of schizophrenia

RS Kahn - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
What have we accomplished for schizophrenia patients since the introduction of
chlorpromazine in 1952 (1)? Have we really made a difference in the outcome of …

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

E Alkan, G Davies, SL Evans - npj Schizophrenia, 2021 - nature.com
Cognitive impairments are a core and persistent characteristic of schizophrenia with
implications for daily functioning. These show only limited response to antipsychotic …

Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US veterans

TB Bigdeli, AH Fanous, Y Li, N Rajeevan… - Schizophrenia …, 2021 - academic.oup.com
Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating
neuropsychiatric disorders, collectively affecting 2% of the world's population. Recognizing …

Accuracy of immediate self-assessment of neurocognitive test performance: associations with psychiatric diagnosis and longitudinal psychotic symptoms

O Morgan, MT Strassnig, RC Moore, CA Depp… - Journal of psychiatric …, 2022 - Elsevier
Participants with schizophrenia (SCZ) and bipolar disorder (BD) have challenges in self-
evaluation of their cognitive and functional abilities, referred to as introspective accuracy …

Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders

S Eum, SK Hill, N Alliey-Rodriguez… - …, 2021 - nature.com
Identifying genetic contributors to cognitive impairments in psychosis-spectrum disorders
can advance understanding of disease pathophysiology. Although CNS medications are …

[HTML][HTML] Neurocognitive variability in schizophrenia spectrum disorders: relationship to real-world functioning

L Helldin, C Mohn, AK Olsson, F Hjärthag - Schizophrenia Research …, 2020 - Elsevier
Neurocognitive variability exists within the schizophrenia spectrum disorder (SSD)
population, with subgroups performing at the same level as healthy samples Here we study …

Cross-diagnostic determinants of cognitive functioning: the muscarinic cholinergic receptor as a model system

SE Jones, PD Harvey - Translational psychiatry, 2023 - nature.com
Cognitive impairment is a predictor of disability across different neuropsychiatric conditions,
and cognitive abilities are also strongly related to educational attainment and indices of life …

[HTML][HTML] Returning individual research results to vulnerable individuals

CL Kolarcik, MJ Bledsoe, TJ O'Leary - The American Journal of Pathology, 2022 - Elsevier
Although issues associated with returning individual research results to study participants
have been well explored, these issues have been less thoroughly investigated in vulnerable …

Imputed expression of schizophrenia‐associated genes and cognitive measures in patients with schizophrenia

C Fabbri, GM Leggio, F Drago… - Molecular genetics & …, 2022 - Wiley Online Library
Background Cognitive dysfunction is a core manifestation of schizophrenia and one of the
best predictors of long‐term disability. Genes increasing risk for schizophrenia may partly act …