Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …

The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on
intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously …

We present EMAN (Electron Micrograph ANalysis), a software package for performing
semiautomated single-particle reconstructions from transmission electron micrographs. The …

This Meeting Review describes the proceedings and conclusions from the inaugural
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

The ryanodine receptor (RyR) is a high-conductance Ca2+ channel of the sarcoplasmic
reticulum in muscle and of the endoplasmic reticulum in other cells. In striated muscle fibers …

1. Introduction 3082. Electron microscopy 3112.1 Specimen preparation 3112.2 The
electron microscope 3112.3 Acceleration voltage, defocus, and the electron gun 3122.4 …

Inositol 1, 4, 5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …

Eukaryotic organelles can interact with each other through stable junctions where the two
membranes are kept in close apposition. The junction that connects the endoplasmic …

This is a quantitative model of control of Ca2+ release from the sarcoplasmic reticulum in
skeletal muscle, based on dual control of release channels (ryanodine receptors), primarily …