Constitutive immune mechanisms: mediators of host defence and immune regulation
The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …
challenges. Immune responses can be evoked through diverse inducible pathways …
APOBEC enzymes as targets for virus and cancer therapy
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68
Y Wang, SA Tibbetts, LT Krug - Annual review of virology, 2021 - annualreviews.org
Gammaherpesviruses are an important class of oncogenic pathogens that are exquisitely
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …
Human APOBEC3 variations and viral infection
S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
[HTML][HTML] Roles of APOBEC3A and APOBEC3B in human papillomavirus infection and disease progression
The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome
S Dallari, T Heaney, A Rosas-Villegas, JA Neil… - Cell host & …, 2021 - cell.com
The contributions of the viral component of the microbiome—the virome—to the
development of innate and adaptive immunity are largely unknown. Here, we systematically …
development of innate and adaptive immunity are largely unknown. Here, we systematically …
The role of APOBECs in viral replication
WK Xu, H Byun, JP Dudley - Microorganisms, 2020 - mdpi.com
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
[PDF][PDF] Adipocyte death preferentially induces liver injury and inflammation through the activation of chemokine (C‐C motif) receptor 2‐positive macrophages and …
Adipocyte death occurs under various physiopathological conditions, including obesity and
alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying …
alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying …
Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat
HIV-1 integrates into the genome of target cells and establishes latency indefinitely.
Understanding the molecular mechanism of HIV-1 latency maintenance is needed for …
Understanding the molecular mechanism of HIV-1 latency maintenance is needed for …
A conserved mechanism of APOBEC3 relocalization by herpesviral ribonucleotide reductase large subunits
An integral part of the antiviral innate immune response is the APOBEC3 family of single-
stranded DNA cytosine deaminases, which inhibits virus replication through deamination …
stranded DNA cytosine deaminases, which inhibits virus replication through deamination …