Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

AR Tejedor, I Sanchez-Burgos… - Nature …, 2022 - nature.com
Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …

Rotaxane Formation of Multicyclic Polydimethylsiloxane in a Silicone Network: A Step toward Constructing “Macro‐Rotaxanes” from High‐Molecular‐Weight Axle and …

M Ebe, A Soga, K Fujiwara, BJ Ree… - Angewandte …, 2023 - Wiley Online Library
Rotaxanes consisting of a high‐molecular‐weight axle and wheel components (macro‐
rotaxanes) have high structural freedom, and are attractive for soft‐material applications …

Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

Nucleation and crystallization of polymer melts under cyclic stretching: entanglement effect

C Zhu, J Zhao - Macromolecules, 2023 - ACS Publications
It is well known that the local orientation order plays a key role in stretch-induced nucleation
and crystal growth of polymer melts, where a competition between chain orientation and …

[HTML][HTML] Composite entanglement topology and extensional rheology of symmetric ring-linear polymer blends

TC O'Connor, T Ge, GS Grest - Journal of Rheology, 2022 - pubs.aip.org
Extensive molecular simulations are applied to characterize the equilibrium dynamics,
entanglement topology, and nonlinear extensional rheology of symmetric ring-linear …

Molecular dynamics simulations of ring shapes on a ring fraction in ring–linear polymer blends

K Hagita, T Murashima - Macromolecules, 2021 - ACS Publications
Threading of a linear chain through a ring has been known to have a strong effect on
slowing the dynamics of the ring. To enhance the toughness of soft materials using ring …

All-Atom Molecular Dynamics Simulations of Poly (ethylene glycol) Networks in Water for Evaluating Negative Energetic Elasticity

K Hagita, S Nagahara, T Murashima, T Sakai… - …, 2023 - ACS Publications
We performed all-atom molecular dynamics simulations on poly (ethylene glycol)(PEG)
hydrogels to microscopically confirm the recently discovered “negative energetic …

Measuring topological constraint relaxation in ring-linear polymer blends

DL Vigil, T Ge, M Rubinstein, TC O'Connor, GS Grest - Physical Review Letters, 2024 - APS
Polymers are an effective test bed for studying topological constraints in condensed matter
due to a wide array of synthetically available chain topologies. When linear and ring …

Location and Concentration of Aromatic‐Rich Segments Dictates the Percolating Inter‐Molecular Network and Viscoelastic Properties of Ageing Condensates

S Blazquez, I Sanchez‐Burgos, J Ramirez… - Advanced …, 2023 - Wiley Online Library
Maturation of functional liquid‐like biomolecular condensates into solid‐like aggregates has
been linked to the onset of several neurodegenerative disorders. Low‐complexity aromatic …

Effect of threading on static and dynamic properties of polymer chains in entangled linear-ring blend systems with different stiffness

W Wang, J Lu, R Sun - Polymer, 2024 - Elsevier
Threading is a unique topological state in linear/ring polymer blends (LRB), which is
considered to be essential for evaluating both the static and dynamic properties of ring …