Abstract The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-
phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the …

L egionella species are ubiquitous, waterborne bacteria that thrive in numerous ecological
niches. Yet, in contrast to many other environmental bacteria, L egionella spp. are also able …

Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

The activity of proteins delivered into host cells by the Dot/Icm injection apparatus allows
Legionella pneumophila to establish a niche called the Legionella-containing vacuole …

The environmental bacterium Legionella pneumophila replicates in free-living amoeba as
well as in alveolar macrophages upon inhalation of bacteria-laden aerosols. Resistance of …

Legionella pneumophila, a Gram-negative intracellular bacterium, is one of the major
causes of Legionnaires' disease, a specific type of atypical pneumonia. Despite intensive …

Protein ubiquitination is critical for regulation of numerous eukaryotic cellular processes
such as protein homeostasis, cell cycle progression, immune response, DNA repair, and …

The opportunistic intracellular pathogen Legionella pneumophila is the causative agent of
Legionnaires' disease. L. pneumophila delivers nearly 300 effector proteins into host cells …

The intracellular bacterial pathogen Coxiella burnetii directs biogenesis of a
parasitophorous vacuole (PV) that acquires host endolysosomal components. Formation of …

Pathogenic bacteria are in a constant battle for survival with their host. In order to gain a
competitive edge, they employ a variety of sophisticated strategies that allow them to modify …