BACKGROUND Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in
their function leading to decreased insulin secretion or may arise from insulin resistance and …

Diabetes mellitus (DM) represents one of the greatest threats to human health all over the
world. The incidence of DM is rising rapidly also including children and young persons of …

Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

The excessive intake of fructose in the regular human diet could be related to global
increases in metabolic disorders. Sugar-sweetened soft drinks, mostly consumed by …

Diabetes is a considerate metabolic disorder that can lead to a series of complications,
involving the malfunctioning of the reproductive system of males. It has been observed that …

Background Owing to the early suffering age and the rising incidence of type 1 diabetes
(T1D), the resulting male reproductive dysfunction and fertility decline have become a …

Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men.
Over the years, in order to solve this growing problem, a lot of research has been done and …

Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs
governing mammalian spermatogenesis but fails to delineate their dynamics in the native …

Background/Aims. Obesity, which is related to increased oxidative stress in various tissues,
is a risk factor for male infertility. Metformin is reported to have an antioxidant effect; …

Individuals with diabetes mellitus (DM) present marked reduction in sperm quality and
higher DNA damage in spermatozoa, evidencing that this metabolic disorder impairs male …