[HTML][HTML] Dorsal Dentate Gyrus, a key regulator for mood and psychiatric disorders

D Sun, L Mei, WC Xiong - Biological psychiatry, 2023 - Elsevier
The dentate gyrus, a “gate” that controls the flow of information into the hippocampus, is
critical for learning, memory, spatial navigation, and mood regulation. Several lines of …

Low-density lipoprotein receptor-related protein 8 at the crossroad between cancer and neurodegeneration

D Passarella, S Ciampi, V Di Liberto… - International journal of …, 2022 - mdpi.com
The low-density-lipoprotein receptors represent a family of pleiotropic cell surface receptors
involved in lipid homeostasis, cell migration, proliferation and differentiation. The family …

Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones

D Karademir, V Todorova, LJA Ebner, M Samardzija… - BMC biology, 2022 - Springer
Background In inherited retinal disorders such as retinitis pigmentosa (RP), rod
photoreceptor-specific mutations cause primary rod degeneration that is followed by …

Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

R Cao, P Chen, H Wang, H Jing, H Zhang… - Nature …, 2023 - nature.com
Proprioception is sensed by muscle spindles for precise locomotion and body posture.
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …

A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance

H Zhang, W Chen, Z Tan, L Zhang, Z Dong… - Journal of …, 2020 - Soc Neuroscience
Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …

Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis …

G Ayyubova, M Kodali, R Upadhya, LN Madhu… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural
stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating …

Modulatory properties of extracellular matrix glycosaminoglycans and proteoglycans on neural stem cells behavior: Highlights on regenerative potential and bioactivity

Z Shabani, T Ghadiri, M Karimipour… - International Journal of …, 2021 - Elsevier
Despite the poor regenerative capacity of the adult central nervous system (CNS) in
mammals, two distinct regions, subventricular zone (SVZ) and the subgranular zone (SGZ) …

[HTML][HTML] ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

N Tabrizian, S Nouruzi, CJ Cui, M Kobelev… - Cell Reports, 2023 - cell.com
Lineage plasticity is a form of therapy-induced drug resistance. In prostate cancer, androgen
receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss …

[HTML][HTML] AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target

H Zhang, J Liang, T Lu, M Li, G Shan, G Bi… - Pharmacological …, 2023 - Elsevier
Lung cancer is the main reason for cancer-associated death globally, and lung
adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Recently, AGRN is …

Vascular endothelial cells: a fundamental approach for brain waste clearance

H Wei, H Jiang, Y Zhou, X Xiao, C Zhou, X Ji - Brain, 2023 - academic.oup.com
Accumulation of neurotoxic protein aggregates is the pathological hallmark of
neurodegenerative disease. Proper clearance of these waste metabolites is an essential …