[HTML][HTML] Dorsal Dentate Gyrus, a key regulator for mood and psychiatric disorders
The dentate gyrus, a “gate” that controls the flow of information into the hippocampus, is
critical for learning, memory, spatial navigation, and mood regulation. Several lines of …
critical for learning, memory, spatial navigation, and mood regulation. Several lines of …
Low-density lipoprotein receptor-related protein 8 at the crossroad between cancer and neurodegeneration
D Passarella, S Ciampi, V Di Liberto… - International journal of …, 2022 - mdpi.com
The low-density-lipoprotein receptors represent a family of pleiotropic cell surface receptors
involved in lipid homeostasis, cell migration, proliferation and differentiation. The family …
involved in lipid homeostasis, cell migration, proliferation and differentiation. The family …
Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
D Karademir, V Todorova, LJA Ebner, M Samardzija… - BMC biology, 2022 - Springer
Background In inherited retinal disorders such as retinitis pigmentosa (RP), rod
photoreceptor-specific mutations cause primary rod degeneration that is followed by …
photoreceptor-specific mutations cause primary rod degeneration that is followed by …
Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals
Proprioception is sensed by muscle spindles for precise locomotion and body posture.
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …
A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis …
Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural
stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating …
stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating …
Modulatory properties of extracellular matrix glycosaminoglycans and proteoglycans on neural stem cells behavior: Highlights on regenerative potential and bioactivity
Despite the poor regenerative capacity of the adult central nervous system (CNS) in
mammals, two distinct regions, subventricular zone (SVZ) and the subgranular zone (SGZ) …
mammals, two distinct regions, subventricular zone (SVZ) and the subgranular zone (SGZ) …
[HTML][HTML] ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
N Tabrizian, S Nouruzi, CJ Cui, M Kobelev… - Cell Reports, 2023 - cell.com
Lineage plasticity is a form of therapy-induced drug resistance. In prostate cancer, androgen
receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss …
receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss …
[HTML][HTML] AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target
H Zhang, J Liang, T Lu, M Li, G Shan, G Bi… - Pharmacological …, 2023 - Elsevier
Lung cancer is the main reason for cancer-associated death globally, and lung
adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Recently, AGRN is …
adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Recently, AGRN is …
Vascular endothelial cells: a fundamental approach for brain waste clearance
H Wei, H Jiang, Y Zhou, X Xiao, C Zhou, X Ji - Brain, 2023 - academic.oup.com
Accumulation of neurotoxic protein aggregates is the pathological hallmark of
neurodegenerative disease. Proper clearance of these waste metabolites is an essential …
neurodegenerative disease. Proper clearance of these waste metabolites is an essential …