Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century

WH Lee, CY Loo, M Bebawy, F Luk… - Current …, 2013 - ingentaconnect.com
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

The mechanisms of action of curcumin in Alzheimer's disease

M Tang, C Taghibiglou - Journal of Alzheimer's disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence
of AD rises in the 21st century, there is an urgent need for the development of effective …

[HTML][HTML] The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies

SD Voulgaropoulou, T Van Amelsvoort, J Prickaerts… - Brain research, 2019 - Elsevier
Alzheimer's disease constitutes a growing cause of cognitive impairment in aging
population. Given that current treatments do not produce the desired therapeutic effects, the …

A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)

Y Chen, Z Liang, J Blanchard, CL Dai, S Sun… - Molecular …, 2013 - Springer
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and result from multiple etiologic factors, including …

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research

M Salkovic-Petrisic, A Knezovic, S Hoyer… - Journal of neural …, 2013 - Springer
Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of …

TB Bassani, JM Turnes, ELR Moura, JM Bonato… - Behavioural brain …, 2017 - Elsevier
Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and
neuroprotective properties. Recent evidence also suggests that curcumin increases …

Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system

J Lee, DG Jo, D Park, HY Chung, MP Mattson… - Pharmacological …, 2014 - Elsevier
During the past 5 decades, it has been widely promulgated that the chemicals in plants that
are good for health act as direct scavengers of free radicals. Here we review evidence that …

Indian medicinal herbs and formulations for Alzheimer's disease, from traditional knowledge to scientific assessment

J Mehla, P Gupta, M Pahuja, D Diwan, D Diksha - Brain sciences, 2020 - mdpi.com
Cognitive impairment, associated with ageing, stress, hypertension and various
neurodegenerative disorders including Parkinson's disease and epilepsy, is a major health …

Action mechanisms of curcumin in Alzheimer's disease and its brain targeted delivery

D Ege - Materials, 2021 - mdpi.com
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as
Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer's disease …

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK 3β Pathway in Streptozotocin‐Induced A …

C Gao, Y Liu, Y Jiang, J Ding, L Li - Brain pathology, 2014 - Wiley Online Library
Intracerebral‐ventricular (ICV) injection of streptozotocin (STZ) induces an insulin‐resistant
brain state that may underlie the neural pathogenesis of sporadic A lzheimer disease (AD) …