The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Abstract The Keap1–Nrf2–ARE ((Kelch‐like ECH‐Associating protein 1) nuclear factor
erythroid 2 related factor 2‐antioxidant response element) pathway is one of the most …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy.
Studies in experimental animal models of diabetes strongly implicate oxidant species as a …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-
inflammatory properties that can regulate multiple cardiovascular functions. However, its …

Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Diabetes is considered a major burden on the healthcare system of Western and non‐
Western societies with the disease reaching epidemic proportions globally. Diabetic patients …

The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …