Sáez, Juan C., Viviana M. Berthoud, María C. Brañes, Agustín D. Martínez, and Eric C.
Beyer. Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions …

Gap junctions (GJs) are the only known cellular structures that allow a direct transfer of
signaling molecules from cell-to-cell by forming hydrophilic channels that bridge the …

Hearing impairment (HI) affects 1 in 650 newborns, which makes it the most common
congenital sensory impairment. Despite extraordinary genetic heterogeneity, mutations in …

Hearing impairment is the most commonly occurring condition that affects the ability of
humans to communicate 1. More than 50% of the cases of profound early-onset deafness …

Gap junction membrane channels mediate electrical and metabolic coupling between
adjacent cells. The structure of a recombinant cardiac gap junction channel was determined …

Hereditary deafness has proved to be extremely heterogeneous genetically with more than
40 genes mapped or cloned for non-syndromic dominant deafness and 30 for autosomal …

▪ Abstract Hereditary isolated hearing loss is genetically highly heterogeneous. Over 100
genes are predicted to cause this disorder in humans. Sixty loci have been reported and 24 …

correspondence 16 nature genetics• volume 23• september 1999 light of speculation that
some form of DNA rearrangement is involved during the selective expression of individual …

▪ Abstract Intercellular channels present in gap junctions allow cells to share small
molecules and thus coordinate a wide range of behaviors. Remarkably, although junctions …

Introduction: Mutations in GJB2 are the most common cause of non-syndromic autosomal
recessive hearing impairment, ranging from mild to profound. Mutation analysis of this gene …