For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the
primary basis and best functional correlate of immunological protection. Durable long-term …

Following infection or vaccination, activated B cells at extrafollicular sites or within germinal
centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been …

Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the
bone marrow. Multiple myeloma cells are characterized by distinctive biological features that …

Epithelial-to-mesenchymal transition (EMT) promotes both tumor progression and drug
resistance, yet few vulnerabilities of this state have been identified. Using selective small …

Bacterially derived lipopolysaccharide (LPS) stimulates naive B lymphocytes to differentiate
into immunoglobulin (Ig)-secreting plasma cells. Differentiation of B lymphocytes is …

During infection, cellular resources are allocated toward the metabolically-demanding
processes of synthesizing and secreting effector proteins that neutralize and kill invading …

When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell
receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These …

Summary Weibel-Palade bodies (WPBs), endothelial-specific secretory granules that are
central to primary hemostasis and inflammation, occur in dimensions ranging between 0.5 …

TENT5C is a non-canonical cytoplasmic poly (A) polymerase highly expressed by activated
B cells to suppress their proliferation. Here we measure the global distribution of poly (A) tail …

Abstract Bortezomib induces remissions in 30%-50% of patients with relapsed mantle cell
lymphoma (MCL). Conversely, more than half of patients' tumors are intrinsically resistant to …