Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Alzheimer's disease (AD) is characterized by brain plaques, tangles, and cognitive
impairment. AD is one of the most common age-related dementias in humans. Progress in …

Canine cognitive dysfunction (CCD) is a form of dementia that shares many similarities with
Alzheimer's disease. Given that physical activity is believed to reduce risk of Alzheimer's …

Animals and animal models have been invaluable for our current understanding of human
and animal biology, including physiology, pharmacology, biochemistry, and disease …

Canine cognitive dysfunction (CCD) is a highly prevalent neurodegenerative disease
considered the canine analog of early Alzheimer's disease (AD). Unfortunately, CCD cannot …

Objectives The aim of this study was to investigate the potential risk factors involved in the
development of presumptive advanced canine cognitive dysfunction (pACCD). Materials …

The successful development and translation of PET imaging agents targeting β-amyloid
plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these …

Canine cognitive dysfunction (CCD) syndrome is a well-recognized naturally occurring
disease in aged dogs, with a remarkably similar disease course, both in its clinical …

Our previous study indicated that inhibition of NLRP1-dependent pyroptosis could decrease
intracerebroventricular (ICV) injection of a protein kinase A (PKA) agonist–or streptozotocin …

Background Older companion dogs naturally develop a dementia-like syndrome with
biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has …