Oxidative stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the pathogenesis and treatment of aging‐related diseases
Y Li, T Zhao, J Li, M Xia, Y Li, X Wang… - Journal of …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …
Halogenated antimicrobial agents to combat drug-resistant pathogens
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents
RH Abd El-Hameed, AI Sayed… - Journal of Enzyme …, 2021 - Taylor & Francis
Pyrroles and its fused forms possess antimicrobial activities, they can easily interact with
biomolecules of living systems. A series of substituted pyrroles, and its fused pyrimidines …
biomolecules of living systems. A series of substituted pyrroles, and its fused pyrimidines …
Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors
To front emergence of antibiotic resistance there is an urgent need for new therapeutics, and
one seemingly relevant target is thymidylate monophosphate kinase (TMPK) …
one seemingly relevant target is thymidylate monophosphate kinase (TMPK) …
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
CE Olsen, FH Blindheim, CK Søgaard, LM Røst… - Antibiotics, 2022 - mdpi.com
Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals
and public healthcare systems. At the same time drug development is lagging behind …
and public healthcare systems. At the same time drug development is lagging behind …
The literature of heterocyclic chemistry, part XVIII, 2018
LI Belen'kii, GA Gazieva, YB Evdokimenkova… - Advances in …, 2020 - Elsevier
The literature of heterocyclic chemistry, part XVIII, 2018 - ScienceDirect Skip to main contentSkip
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full …
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full …
Pyridazinone based derivatives as anticancer agents endowed with anti-microbial activity; Molecular design, synthesis, and biological investigation
M Elnagar, MI Shahin, M El-Behairy… - RSC Medicinal …, 2024 - pubs.rsc.org
Cancer patients undergoing chemotherapy are highly susceptible to infections due to their
compromised immune systems, which also promote cancer progression through …
compromised immune systems, which also promote cancer progression through …
Coumarin–furo [2, 3-d] pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies
T Wang, Y Gao, F Wu, L Luo, J Ma, Y Hu - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The design, synthesis and investigation of antitumor activities of some coumarin–furo [2, 3-d]
pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the …
pyrimidone hybrid molecules are reported. In vitro, HepG2 cells were used to investigate the …
Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation
Novel symmetrical bis-pyrrolo [2, 3-d] pyrimidines and bis-purines and their monomers were
synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma …
synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma …
An expedient approach for the regioselective synthesis of novel 1, 5, 6, 7-tetrahydro-2H-pyrrolo [3, 2-d] pyrimidine-2, 4 (3H, 5H)-dione derivatives via Fe (III)-mediated …
S Samanta, S Mondal - Tetrahedron Letters, 2022 - Elsevier
Abstract Novel pyrrolo [3, 2-d] pyrimidine derivatives have been synthesized by an efficient
and regioselective Fe (III)-mediated iodocyclization method starting from a commercially …
and regioselective Fe (III)-mediated iodocyclization method starting from a commercially …