This review summarizes the latest advances that have been made to elucidate the
somatostatinergic system in respect to somatostatin receptor evolution, the development of …

The biological effects of somatostatin (SST) were first encountered unexpectedly in the late
1960s in two unrelated studies, one by Krulich et al.(1968) who reported on a growth …

in vivo microdialysis was used to investigate whether nitric oxide (NO) modulates striatal
neurotransmitter release in the rat through inducing cyclic GMP formation via soluble …

It has long been considered that somatostatin acts as a neuromodulator in the mammalian
central nervous system but its precise physiological roles remain elusive. Early studies to …

As cotreatment of somatostatin (SRIF) and dopamine (DA) agonists reduces GH in
acromegaly more effectively than either agonist alone, SRIF and DA receptors (SSTR and …

Since the discovery of striatal neurons expressing dopamine-synthesizing enzymes,
researchers have attempted to identify their phenotype and functional significance. In this …

The peptide somatostatin can modulate the functional output of the basal ganglia. The exact
sites and mechanisms of this action, however, are poorly understood, and the physiological …

The peptide hormone/neurotransmitter somatostatin (somatotropin release inhibiting factor;
SRIF) and its receptors (sst1–sst5) appear to regulate many physiological functions in the …

Dopamine and somatostatin have been implicated in the pathophysiology of depression. We
have employed in vivo microdialysis to investigate the regulation of dopamine release by …

In the retina, somatostatin (SRIF) acts as a neuromodulator by interacting with specific SRIF
subtype (sst) receptors. The aim of this study was to detect mRNAs for sst1–5 receptors by …