Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

The basic functional unit of the large‐conductance, voltage‐and Ca2+‐activated K+ (MaxiK,
BK, BKCa) channel is a tetramer of the pore‐forming α‐subunit (MaxiKα) encoded by a …

Abstract Changes in cellular Ca2+ levels have major influences on vascular function and
blood pressure regulation. Vascular smooth muscle cells (SMCs) and endothelial cells …

Myogenic, or pressure-induced, vasoconstriction is critical for local blood flow
autoregulation. Underlying this vascular smooth muscle (VSM) response are events …

Cardiovascular diseases are the main cause of morbidity and mortality in the Western
society and ageing is a relevant non-modifiable risk factor. Morphological and functional …

Penile erection is dependent on the nitric oxide (NO)/cGMP‐dependent protein kinase I
(PKGI) pathway. One important target of PKGI in smooth muscle is the large‐conductance …

K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …