Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that …

Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-
mesenchymal transition, but whether cardiac fibroblasts can adopt an endothelial cell fate …

Many organs rely on undifferentiated stem and progenitor cells for tissue regeneration.
Whether differentiated cells themselves can contribute to cell replacement and tissue …

The limited vessel-forming capacity of infused endothelial progenitor cells (EPCs) into
patients with cardiovascular dysfunction may be related to a misunderstanding of the …

The identification of cardiac progenitor cells in mammals raises the possibility that the
human heart contains a population of stem cells capable of generating cardiomyocytes and …

Cancer therapy has progressed remarkably in recent years. In no area has this been more
apparent than in the development of'targeted therapies', particularly those using drugs that …

Colony-forming units–fibroblast (CFU-Fs), analogous to those giving rise to bone marrow
(BM) mesenchymal stem cells (MSCs), are present in many organs, although the …

An emerging concept is that the mammalian myocardium has the potential to regenerate, but
that regeneration might be too inefficient to repair the extensive myocardial injury that is …

Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …