Potential role of plasmalogens in the modulation of biomembrane morphology

ZA Almsherqi - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Plasmalogens are a subclass of cell membrane glycerophospholipids that typically include
vinyl-ether bond at the sn-1 position and polyunsaturated fatty acid at the sn-2 position. They …

[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Composition-switchable liquid crystalline nanostructures as green formulations of curcumin and fish oil

M Rakotoarisoa, B Angelov, S Espinoza… - ACS Sustainable …, 2021 - ACS Publications
Green compositions and processes for fabrication of dual-and multiloaded nanocarriers with
an antioxidant functionality and neuroprotective, cardioprotective, antiviral, and …

[HTML][HTML] Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin …

M Rakotoarisoa, B Angelov, M Drechsler… - Smart Materials in …, 2022 - Elsevier
We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting
of endoplasmic reticulum stress as a potential emerging therapeutic strategy against …

Recent uses of lipid nanoparticles, cell-penetrating and bioactive peptides for the development of brain-targeted nanomedicines against neurodegenerative disorders

Y Wu, A Angelova - Nanomaterials, 2023 - mdpi.com
The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …

Sustained CREB phosphorylation by lipid-peptide liquid crystalline nanoassemblies

Y Wu, B Angelov, Y Deng, T Fujino… - Communications …, 2023 - nature.com
Cyclic-AMP-response element-binding protein (CREB) is a leucine zipper class transcription
factor that is activated through phosphorylation. Ample CREB phosphorylation is required for …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

Self-assembled nanoscale materials for neuronal regeneration: a focus on BDNF protein and nucleic acid biotherapeutic delivery

Y Wu, M Rakotoarisoa, B Angelov, Y Deng, A Angelova - Nanomaterials, 2022 - mdpi.com
Enabling challenging applications of nanomedicine and precision medicine in the treatment
of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated …

Phase behavior of soybean phosphatidylcholine and glycerol dioleate in hydrated and dehydrated states studied by small-angle X-ray scattering

J Engstedt, J Barauskas, V Kocherbitov - Soft Matter, 2023 - pubs.rsc.org
Soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) form liquid crystal
nanostructures in aqueous environments, and their mixtures can effectively encapsulate …

Omega‐3 polyunsaturated fatty acids and its metabolite 12‐HEPE rescue busulfan disrupted spermatogenesis via target to GPR120

J Jing, L Ouyang, H Zhang, K Liang, R Ma… - Cell …, 2024 - Wiley Online Library
Busulfan is an antineoplastic, which is always accompanied with the abnormal of
spermatogonia self‐renewal and differentiation. It has been demonstrated that the omega‐3 …