Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …

Sepsis-related organ dysfunction remains the most common cause of death in the intensive
care unit (ICU), despite advances in healthcare and science. Marked oxidative stress as a …

Mitochondrial dysfunction is increasingly recognized as an accomplice in most of the
common human diseases including cancer, neurodegeneration, diabetes …

Resuscitation of the critically ill patient should be aimed at the reversal of tissue hypoxia.
The use of lactate as a hemodynamic marker and resuscitation endpoint makes physiologic …

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence
of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model …

The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and
septic shock have been the subject of investigations for nearly half a century. Controversies …

Sepsis is a leading cause of death in medical and surgical intensive care units (ICUs).
Disturbance of consciousness of varying severity is an early warning sign of developing …

Objective: Increasing evidence implicates mitochondrial dysfunction as an early, important
event in the pathogenesis of critical illness-induced multiple organ failure. We previously …