Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

Background Radiotherapy is a conventional and effective local treatment for breast cancer.
However, residual or recurrent tumors appears frequently because of radioresistance. Novel …

Kruppel-associated box (KRAB) zinc-finger proteins (KRAB-ZFPs) are the largest
transcriptional/transcription-regulatory factor family in mammalian cells. The amino-terminal …

Background In spite of great progress in the surgical and clinical management, until now no
significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) …

The early specification and rapid growth of extraembryonic membranes are distinctive
hallmarks of primate embryogenesis. These complex tasks are resolved through an intricate …

Huntington's disease (HD) is a neurodegenerative disorder caused by CAG-repeat
expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces …

Simple Summary A large number of estrogen receptor-positive breast cancer patients show
relapses at the metastatic site up to 20 years after the removal of the primary tumor. This …