Cluster headache is a trigeminal autonomic cephalalgia characterised by extremely painful,
strictly unilateral, short-lasting headache attacks accompanied by ipsilateral autonomic …

Cluster headache is an excruciating, strictly one-sided pain syndrome with attacks that last
between 15 minutes and 180 minutes and that are accompanied by marked ipsilateral …

The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

Circadian rhythms are a nearly universal feature of living organisms and affect almost every
biological process. Our innate preference for mornings or evenings is determined by the …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

Cluster headache is a primary headache disorder affecting up to 0.1% of the population.
Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day …

The neuropeptides orexins are important in regulating the neurobiological systems that
respond to stressful stimuli. Furthermore, orexins are known to play a role many of the …

Cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform
headache attacks with conjunctival injection and tearing (SUNCT) are primary headaches …

Objective Identifying common genetic variants that confer genetic risk for cluster headache.
Methods We conducted a case–control study in the Dutch Leiden University Cluster …

Orexin signaling is essential for normal regulation of arousal and behavioral state control
and represents an attractive target for therapeutics combating insomnia. Alternatively termed …