Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Prenatal and postnatal treatment modalities for congenital diaphragmatic hernia (CDH)
continue to improve, however patients still face high rates of morbidity and mortality caused …

FGF signaling plays an essential role in lung development, homeostasis, and regeneration.
We employed mouse 3D cell culture models and imaging to study ex vivo the role of FGF …

Idiopathic lung fibrosis (IPF) is a fatal lung disease characterized by chronic epithelial injury
and exhausted repair capacity of the alveolar compartment, associated with the expansion …

Airway branching morphogenesis depends on the intricate orchestration of numerous
biological and physical factors connected across different spatial scales. One of the key …

A common developmental process, called branching morphogenesis, generates the
epithelial trees in a variety of organs, including the lungs, kidneys, and glands. How …

Silicosis is a fatal occupational lung disease which currently has no effective clinical cure.
Recent studies examining the underlying mechanism of silicosis have primarily examined …

Complex human airway cellular organization where extracellular matrix (ECM) and
epithelial and stromal lineages interact present challenges for organ study in vitro. Current in …

Fibroblast growth factors (FGFs) 9 and 10 are essential during the pseudoglandular stage of
lung development. Mesothelium-produced FGF9 is principally responsible for mesenchymal …