The concept of bifunctional catalysis, wherein both partners of a bimolecular reaction are
simultaneously activated, is very powerful for designing efficient asymmetric catalysts …

Despite being a common viral disease, influenza has very negative consequences, causing
the death of around half a million people each year. A neuraminidase located on the surface …

Influenza remains a major health problem. The worldwide occurrences of avian flu have
increased public awareness of the potential for global influenza pandemics. Tamiflu …

Efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) restricts substrate
compounds from entering the brain and may thus contribute to pharmacoresistance …

Influenza is a serious respiratory disease responsible for significant morbidity and mortality
due to both annual epidemics and pandemics; its treatment involves the use of …

A chemoenzymatic synthesis of the anti-influenza agent Tamiflu® - ScienceDirect Skip to main
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P-glycoprotein (P-gp) plays a pivotal role in limiting the penetration of xenobiotic compounds
into the brain at the blood–brain barrier (BBB), where its expression increases with …

We review here the synthetic strategies for oseltamivir phosphate, an important orally active
anti‐influenza drug. The Roche synthesis utilized naturally occurring shikimic acid as a …

Recent developments in synthetic strategies toward an important anti‐influenza drug,
oseltamivir phosphate, are discussed. The importance of the drug further increased after the …

A novel and high-yielding asymmetric synthesis of oseltamivir phosphate 1 (Tamiflu®) is
described. The target compound 1 was obtained in 55% overall yield via an 11-step …