Cancer immunotherapy in the form of immune checkpoint inhibitors and cellular therapies
has improved the treatment and prognosis of many patients. Nevertheless, most cancers are …

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune
responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease and is
considered the main cause of dementia worldwide. Genome-wide association studies …

Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging
cancer immunotherapy target. However, limited understanding of its structure and …

Keratan sulfate (KS) is a glycosaminoglycan that is widely expressed in the extracellular
matrix of various tissue types, where it is involved in many biological processes. Herein, we …

The structure of a sialoglycan can be translated into to a biological response when it binds to
a specific endogenous lectin. Among endogenous sialic acid-binding lectins in humans are …

The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …

Widely distributed in nature, sulfated glycan epitopes play important roles in diverse
pathophysiological processes. However, due to their structural complexity, the preparation of …

Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …