Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and developing therapies. Here, we review …

A substantial proportion of cancer patients do not benefit from platinum-based
chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental …

The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-
used gene expression-based classification and has contributed to a better understanding of …

Colorectal cancer (CRC) is traditionally considered to be a genetically driven disease.
However, nongenetic plasticity has recently emerged as a major driver of tumour initiation …

Simple Summary Pancreatic cancer is a deadly disease with limited effective treatments.
Despite growing interest in immunotherapy for other cancer types, immunotherapy has not …