Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …

Subarachnoid hemorrhage (SAH) is an important cause of stroke mortality and morbidity,
especially in the young stroke population. Recent evidences indicate that neuroinflammation …

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in
adults with median survival time of 14.6 months. A small fraction of cancer stem cells (CSC) …

The supply of oxygen and nutrients to the brain is vital for its function and requires a complex
vascular network that, when disturbed, results in profound neurological dysfunction. As part …

Cerebral malaria (CM) is a life-threatening form of Plasmodium falciparum infection caused
by brain inflammation. Brain endothelium dysfunction is a hallmark of CM pathology, which …

Human cerebral malaria (HCM), a severe encephalopathy associated with Plasmodium
falciparum infection, has a 20–30% mortality rate and predominantly affects African children …

Background Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP)
could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a …

Background Human cerebral malaria (HCM) is a severe form of malaria characterized by
sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of …