Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …

Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney
diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study …

Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is
also a serious microvascular complication of diabetes and the main cause of end-stage …

Despite decades of scientific effort, diabetes continues to represent an incredibly complex
and difficult disease to treat. This is due in large part to the multifactorial nature of disease …

Oxidative stress aroused by advanced glycation-end products (AGEs) is a culprit in the
pathological progression of diabetic nephropathy. Both Sirt1 and the Keap1/Nrf2/ARE anti …