This review summarizes reports of recurrent DNA sequence copy number losses in human
neoplasms detected by comparative genomic hybridization. Recurrent losses that affect …

Lung cancer has become the leading cause of cancer death in many economically well-
developed countries. Recent molecular biological studies have revealed that overt lung …

The existence of tumor-suppressor genes was originally demonstrated by functional
complementation through whole-cell and microcell fusion 1, 2. Transfer of chromosome 11 …

The occurrence of aberrations in cell adhesion is a critical phase in the invasion and
metastasis of human cancer. A tumor suppressor gene, TSLC1/IGSF4, from chromosomal …

The Frizzled-type cysteine-rich domain (CRD) is a binding motif for soluble-type glycoprotein
WNTs, which play key roles in embryogenesis and carcinogenesis. Here, we have cloned …

We previously identified TSLC1, a tumor suppressor gene in human nonsmall cell lung
cancer (NSCLC). TSLC1 belongs to immunoglobulin superfamily molecules and is involved …

The TSLC1 tumor-suppressor gene is silenced in a number of human cancer tissues and
cell lines, including lung, prostate, liver, stomach, pancreatic, and breast cancers …

Human chromosome 11q23. 2 has been proposed to contain a tumor suppressor gene (s)
whose deletion has been associated with cancer of the lung and breast and with …

TSLC1 and DAL-1 are tumor suppressor genes involved in cell adhesion. In this study, we
examined the expression and methylation pattern of these genes in breast cancer cell lines …

We recently identified TSLC1, a tumor suppressor gene in human lung cancer. Gene
silencing by promoter methylation has been observed frequently in adenocarcinoma of the …