Preclinical animal anxiety research–flaws and prejudices
A Ennaceur, PL Chazot - Pharmacology research & …, 2016 - Wiley Online Library
The current tests of anxiety in mice and rats used in preclinical research include the elevated
plus‐maze (EPM) or zero‐maze (EZM), the light/dark box (LDB), and the open‐field (OF) …
plus‐maze (EPM) or zero‐maze (EZM), the light/dark box (LDB), and the open‐field (OF) …
Ketamine use disorder: preclinical, clinical, and neuroimaging evidence to support proposed mechanisms of actions
Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been
exclusively used as an anesthetic in medicine and has led to new insights into the …
exclusively used as an anesthetic in medicine and has led to new insights into the …
Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats
Background Major depressive disorder afflicts up to 10% of adolescents. However, nearly
50% of those afflicted are considered nonresponsive to available treatments. Ketamine, a …
50% of those afflicted are considered nonresponsive to available treatments. Ketamine, a …
Ketamine and its metabolite,(2R, 6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression
Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …
[HTML][HTML] Chronic administration of the N-methyl-D-aspartate receptor antagonist ketamine improves Rett syndrome phenotype
A Patrizi, N Picard, AJ Simon, G Gunner… - Biological …, 2016 - Elsevier
Background Rett syndrome (RTT) is a neurological disorder caused by mutation of the X-
linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory …
linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory …
Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: Involvement of oxidative stress, glutamate toxicity and caspase-3 …
AY Onaolapo, OJ Ayeni, MO Ogundeji, A Ajao… - Journal of chemical …, 2019 - Elsevier
Ketamine is a dissociative anaesthetic agent whose recreational use amongst adolescents
and young adults is reaching epidemic proportions in a number of countries. While animal …
and young adults is reaching epidemic proportions in a number of countries. While animal …
Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: consequences for the development of post-traumatic stress …
Abstract Intensive Care Unit (ICU) or emergency care patients, exposed to traumatic events,
are at increased risk for Post-Traumatic Stress Disorder (PTSD) development. Commonly …
are at increased risk for Post-Traumatic Stress Disorder (PTSD) development. Commonly …
Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways
The involvement of oxidative, nitrergic, cholinergic and inflammatory alterations have been
reported to contribute to the pathophysiology of schizophrenia, a debilitating …
reported to contribute to the pathophysiology of schizophrenia, a debilitating …
Ketamine evoked disruption of entorhinal and hippocampal spatial maps
Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial
cognition side effects including out-of-body experiences and spatial memory impairments …
cognition side effects including out-of-body experiences and spatial memory impairments …
Antioxidant treatment with N-acetyl cysteine prevents the development of cognitive and social behavioral deficits that result from perinatal ketamine treatment
A Phensy, HE Duzdabanian, S Brewer… - Frontiers in behavioral …, 2017 - frontiersin.org
Alterations of the normal redox state can be found in all stages of schizophrenia, suggesting
a key role for oxidative stress in the etiology and maintenance of the disease …
a key role for oxidative stress in the etiology and maintenance of the disease …