Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …

Objective: To review the underlying pathophysiologic processes of concussive brain injury
and relate these neurometabolic changes to clinical sports-related issues such as injury to …

Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular
glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids …

Traumatic brain injury (TBI) is a risk factor for dementia. Mixed neurodegenerative
pathologies have been described in late survivors of TBI, but the mechanisms driving post …

Cell death was examined by studying the spinal cords of rats subjected to traumatic insults
of mild to moderate severity. Within minutes after mild weight drop impact (a 10 gm weight …

Following cerebral concussion, in which there is no evidence of direct morphological
damage, cells are exposed to an increase in extracellular potassium as well as an …

Traumatic brain injury (TBI) can lead to secondary neuropsychiatric problems that develop
and persist years after injury. Mounting evidence indicates that neuroinflammatory …

Cerebral edema is a major contributor to morbidity associated with traumatic brain injury
(TBI). The methods involved in most rodent models of TBI, including head fixation, opening …

✓ A new model producing diffuse brain injury, without focal brain lesions, has been
developed in rats. This has been achieved by allowing a weight of 450 gm to fall onto a …