The cell cycle is a complex process that involves numerous regulatory proteins that direct
the cell through a specific sequence of events culminating in mitosis and the production of …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular
events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in …

The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either
reconstituted with purified components or in extracts of cells. In contrast, p53 with missense …

Germline mutations of the Brca1 gene are responsible for most cases of familial breast and
ovarian cancers, but somatic mutations are rarely detected in sporadic events. Moreover …

Abstract Schmidt-Ullrich, RK, Dent, P., Grant S., Mikkelsen, RB and Valerie, K. Signal
Transduction and Cellular Radiation Responses. Exposure of cells to ionizing radiation …

Upon DNA damage, p53 has been shown to be modified at a number of N‐terminal
phosphorylation sites including Ser15 and‐33. Here we show that phosphorylation is …

The tumour suppressor p53 prevents tumour formation after DNA damage by halting cell
cycle progression to allow DNA repair or by inducing apoptotic cell death. Loss of wild‐type …

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response
composed of activation of stress signaling and DNA checkpoint functions. These are …