Corneal endothelium is the single layer of cells forming a boundary between the corneal
stroma and anterior chamber. The barrier and “pump” functions of the endothelium are …

Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …

By using the highly sensitive and specific technique of enzyme-linked immunosorbent
assay, we investigated the presence and amount of transforming growth factor-β2 (TGF-β2) …

Trabeculectomy remains the gold-standard surgical method for reduction of intraocular
pressure (IOP) in the management of glaucoma. Reported success rates for trabeculectomy …

Changes in aqueous humor dynamics with age and in glaucoma have been studied for
several decades. More recently, techniques have been developed which confirm earlier …

Genome-editing technologies have ushered in a new era in gene therapy, providing novel
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …

Isoform-specific antibodies to TGF beta 1, TGF beta 2, and TGF beta 3 proteins were
generated and have been used to examine the expression of these factors in the developing …

Purpose.: To measure levels of various inflammatory cytokines in the aqueous humor of
patients with primary open-angle glaucoma (POAG), exfoliation glaucoma (EXG), and senile …

Smads2 and 3 transduce signals of TGF-β from the cell surface to the nucleus. We used
mice with a targeted deletion of Smad3 to study the specific contributions of this signaling …

Publisher Summary This chapter focuses on the structure and function of Transforming
Growth Factor-β (TGF-β). Like many other peptide growth factors, TGF-β is multifunctional …