Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females

CM Capelle, S Ciré, F Hedin, M Hansen… - Nature …, 2023 - nature.com
Neuroinflammation in the brain contributes to the pathogenesis of Parkinson's disease (PD),
but the potential dysregulation of peripheral immunity has not been systematically …

Long COVID symptomatology after 12 months and its impact on quality of life according to initial coronavirus disease 2019 disease severity

A Fischer, L Zhang, A Elbéji, P Wilmes… - Open Forum …, 2022 - academic.oup.com
Background “Long COVID” is characterized by a variety of symptoms and an important
burden for affected people. Our objective was to describe long COVID symptomatology …

Long COVID classification: findings from a clustering analysis in the predi-COVID cohort study

A Fischer, N Badier, L Zhang, A Elbéji… - International Journal of …, 2022 - mdpi.com
The increasing number of people living with Long COVID requires the development of more
personalized care; currently, limited treatment options and rehabilitation programs adapted …

Pre-Omicron vaccine breakthrough infection induces superior cross-neutralization against SARS-CoV-2 Omicron BA. 1 compared to infection alone

ES da Silva, M Kohnen, G Gilson, T Staub… - International Journal of …, 2022 - mdpi.com
SARS-CoV-2 variants raise concern because of their high transmissibility and their ability to
evade neutralizing antibodies elicited by prior infection or by vaccination. Here, we …

Third SARS-CoV-2 vaccination and breakthrough infections enhance humoral and cellular immunity against variants of concern

L Ruhl, JF Kühne, K Beushausen, J Keil… - Frontiers in …, 2023 - frontiersin.org
Introduction SARS-CoV-2 vaccination is the leading strategy to prevent severe courses after
SARS-CoV-2 infection. In our study, we analyzed humoral and cellular immune responses in …

Proinflammatory innate cytokines and distinct metabolomic signatures shape the T cell response in active COVID-19

A Binayke, A Zaheer, J Dandotiya, SK Gupta, S Mani… - Vaccines, 2022 - mdpi.com
The underlying factors contributing to the evolution of SARS-CoV-2-specific T cell responses
during COVID-19 infection remain unidentified. To address this, we characterized innate and …

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid …

MA Limoges, AJI Quenum, MMH Chowdhury… - Frontiers in …, 2023 - frontiersin.org
Background Following SARS-CoV-2 infection a significant proportion of convalescent
individuals develop the post-COVID condition (PCC) that is characterized by wide spectrum …

Microbiome in the nasopharynx: Insights into the impact of COVID-19 severity

D Galeana-Cadena, G Ramirez-Martínez… - Heliyon, 2024 - cell.com
Background The respiratory tract harbors a variety of microbiota, whose composition and
abundance depend on specific site factors, interaction with external factors, and disease …

Pre-Omicron vaccine breakthrough infection induces superior cross-neutralization against SARS-CoV-2 Omicron BA. 1 than primo infection

E Santos da Silva, M Kohnen, G Gilson, T Staub… - medRxiv, 2022 - medrxiv.org
SARS-CoV-2 variants raise concern because of their high transmissibility and their ability to
evade neutralizing antibodies elicited by prior infection or by vaccination. Here we …

Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy

F Hefeng, D Pogorelov, S Bode, X He, J Ramiro-Garcia… - 2024 - researchsquare.com
Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest
success rate (> 95%) for insect venom while a much lower chance for pollen allergy …