[HTML][HTML] CISD2 maintains cellular homeostasis

ZQ Shen, YL Huang, YC Teng, TW Wang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …

The role of autophagy in gastric cancer chemoresistance: friend or foe?

JL Xu, L Yuan, YC Tang, ZY Xu, HD Xu… - Frontiers in Cell and …, 2020 - frontiersin.org
Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …

Single-cell RNA sequencing explored potential therapeutic targets by revealing the tumor microenvironment of neuroblastoma and its expression in cell death

L Sun, W Shao, Z Lin, J Lin, F Zhao, J Yu - Discover Oncology, 2024 - Springer
Background Neuroblastoma (NB) is the most common extracranial solid tumor in childhood
and is closely related to the early development and differentiation of neuroendocrine (NE) …

High expression of CISD2 in relation to adverse outcome and abnormal immune cell infiltration in glioma

F Zhang, HB Cai, HZ Liu, S Gao, B Wang… - Disease …, 2022 - Wiley Online Library
Glioma is a serious disease burden globally, with high mortality and recurrence rates.
CDGSH iron sulfur domain 2 (CISD2) is an evolutionarily conserved protein that is involved …

[HTML][HTML] Adrenal Ganglioneuroblastoma of Adult Onset: A Literature Review

CM Stevens, K Malone, K Dufrene, W Mclean… - Cureus, 2023 - ncbi.nlm.nih.gov
Ganglioneuroblastomas (GNBs) are a rare subtype of neoplastic tumors that arise from the
autonomic nervous system and contain both mature gangliocytes and immature neuroblasts …

Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation …

J Zhang, T Wang, H Zhang, N Li, B Liu… - Toxicology and Applied …, 2024 - Elsevier
CDGSH iron‑sulfur domain 2 (CISD2) is recognized as a ferroptosis-related gene that has
potential as a target for cancer treatment. However, it is still uncertain whether targeting …

New insights of the NEET protein CISD2 reveals distinct features compared to its close mitochondrial homolog mitoNEET

M Salameh, S Riquier, O Guittet, ME Huang, L Vernis… - Biomedicines, 2021 - mdpi.com
Human CISD2 and mitoNEET are two NEET proteins anchored in the endoplasmic reticulum
and mitochondria membranes respectively, with an Fe–S containing domain stretching out …

Overexpression of CISD2 alleviates septic acute kidney injury via activating Sonic Hedgehog signaling pathway

W Wu, J Zhang, F Chen, H Song… - Cellular and Molecular …, 2024 - cellmolbiol.org
Patients with sepsis are often complicated by acute kidney injury (AKI), which greatly
increases mortality. In this study, our purpose was to explore the expression and function of …

CISD2 protects against Erastin induced hepatocellular carcinoma ferroptosis by upregulating FSP1

W Hou, P Long, X Liu, F Liu, J Liang, Y Huang, Q Su… - Oncologie, 2023 - degruyter.com
Objectives CDGSH iron sulfur domain 2 (CISD2) is essential to maintain iron (Fe) and
reactive oxygen species (ROS) homeostasis, and ferroptosis suppressor protein 1 (FSP1) …

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells

N Kavousi - 2022 - keele-repository.worktribe.com
The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit
(PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3 …