Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …
to the rapidly increased prevalence of overweight and obesity. To this point …
Depression and obesity: evidence of shared biological mechanisms
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …
tend to co-occur within individuals. The relationship between these conditions is …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
Genetics and epigenetics in obesity
K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …
markedly increased over the last decades. Obesity maybe considered a heritable trait …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
A link between FTO, ghrelin, and impaired brain food-cue responsivity
E Karra, OG O'Daly, AI Choudhury… - The Journal of …, 2013 - Am Soc Clin Investig
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with
human obesity and obesity-prone behaviors, including increased food intake and a …
human obesity and obesity-prone behaviors, including increased food intake and a …
Genome-wide association study for feed efficiency and growth traits in US beef cattle
CM Seabury, DL Oldeschulte, M Saatchi, JE Beever… - BMC genomics, 2017 - Springer
Background Single nucleotide polymorphism (SNP) arrays for domestic cattle have
catalyzed the identification of genetic markers associated with complex traits for inclusion in …
catalyzed the identification of genetic markers associated with complex traits for inclusion in …
Epitranscriptomic code and its alterations in human disease
RV Kadumuri, SC Janga - Trends in Molecular Medicine, 2018 - cell.com
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA
modifications to date. These developments, together with the recent discovery of writers …
modifications to date. These developments, together with the recent discovery of writers …
Leveraging phenotypic variability to identify genetic interactions in human phenotypes
AR Marderstein, ER Davenport, S Kulm… - The American Journal of …, 2021 - cell.com
Although thousands of loci have been associated with human phenotypes, the role of gene-
environment (GxE) interactions in determining individual risk of human diseases remains …
environment (GxE) interactions in determining individual risk of human diseases remains …
[HTML][HTML] FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis
abstract Background: Studies have suggested that the fat mass and obesity–associated
(FTO) genotype is associated with individual variability in weight loss in response to …
(FTO) genotype is associated with individual variability in weight loss in response to …