Vanadium compounds in medicine

JC Pessoa, S Etcheverry, D Gambino - Coordination chemistry reviews, 2015 - Elsevier
Vanadium is a transition metal that, being ubiquitously distributed in soil, crude oil, water
and air, also found roles in biological systems and is an essential element in most living …

Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities

A Levina, DC Crans, PA Lay - Coordination Chemistry Reviews, 2017 - Elsevier
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

E Del Carpio, L Hernández, C Ciangherotti… - Coordination chemistry …, 2018 - Elsevier
In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes
of tunicates and possibly in mammals, different vanadium-based drugs have been …

New VIV, VIVO, VVO, and VVO2 Systems: Exploring their Interconversion in Solution, Protein Interactions, and Cytotoxicity

A Banerjee, SP Dash, M Mohanty, G Sahu… - Inorganic …, 2020 - ACS Publications
The synthesis and characterization of one oxidoethoxidovanadium (V)[VVO (L1)(OEt)](1)
and two nonoxidovanadium (IV) complexes,[VIV (L2–3) 2](2 and 3), with aroylhydrazone …

Interaction of V IV O–8-hydroxyquinoline species with RNase A: the effect of metal ligands in the protein adduct stabilization

G Ferraro, L Vitale, G Sciortino, F Pisanu… - Inorganic Chemistry …, 2023 - pubs.rsc.org
Herein, we studied the interaction of bovine pancreatic ribonuclease (RNase A) with [VIVO
(8-HQ) 2]–a promising antitrypanosomal, antituberculosis, and antitumor vanadium complex …

Implications of Protein Interaction in the Speciation of Potential VIVO–Pyridinone Drugs

G Ferraro, M Paolillo, G Sciortino, F Pisanu… - Inorganic …, 2023 - ACS Publications
Vanadium complexes (VCs) are promising agents for the treatment, among others, of
diabetes and cancer. The development of vanadium-based drugs is mainly limited by a …

Integrated experimental/computational approaches to characterize the systems formed by vanadium with proteins and enzymes

G Sciortino, JD Maréchal, E Garribba - Inorganic Chemistry Frontiers, 2021 - pubs.rsc.org
Decoding the interactions of transition metal complexes with proteins is still an open
challenge in many fields, like biology and medicinal chemistry, or in the design of de novo …

Prediction of the interaction of metallic moieties with proteins: An update for protein‐ligand docking techniques

G Sciortino… - Journal of …, 2018 - Wiley Online Library
In this article, we present a new approach to expand the range of application of protein‐
ligand docking methods in the prediction of the interaction of coordination complexes (ie …

Structural and spectroscopic studies related to vanadium chemistry and biochemistry

EJ Baran - Coordination Chemistry Reviews, 2024 - Elsevier
Different aspects of the chemistry and biochemistry of vanadium are analyzed in this review.
The preparation and characterization of oxovanadates and polyoxovanadates, including …

ESI-MS study of the interaction of potential oxidovanadium (IV) drugs and amavadin with model proteins

V Ugone, D Sanna, G Sciortino, DC Crans… - Inorganic …, 2020 - ACS Publications
In this study, the binding to lysozyme (Lyz) of four important VIV compounds with antidiabetic
and/or anticancer activity,[VIVO (pic) 2 (H2O)],[VIVO (ma) 2],[VIVO (dhp) 2], and [VIVO (acac) …