Dysbiosis from a microbial and host perspective relative to oral health and disease

C Cugini, N Ramasubbu, VK Tsiagbe… - Frontiers in …, 2021 - frontiersin.org
The significance of microbiology and immunology with regard to caries and periodontal
disease gained substantial clinical or research consideration in the mid 1960's. This …

[HTML][HTML] Global epidemiology of antimicrobial resistance in commensal Neisseria species: a systematic review

T Vanbaelen, C Van Dijck, J Laumen… - International Journal of …, 2022 - Elsevier
Abstract Background Commensal Neisseria species (spp). represent an important reservoir
of antimicrobial resistance genes for pathogenic Neisseria spp. In this systematic review, we …

The biosynthetic landscape of triceptides reveals radical SAM enzymes that catalyze cyclophane formation on Tyr-and His-containing motifs

R Sugiyama, AFL Suarez, Y Morishita… - Journal of the …, 2022 - ACS Publications
Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …

Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

C Chaguza, M Senghore, E Bojang… - Nature …, 2020 - nature.com
Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an
opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage …

Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan-Neisseria Genome. A Viewpoint

C Kenyon, J Laumen, S Manoharan-Basil - Antibiotics, 2021 - mdpi.com
The development of new gonorrhoea treatment guidelines typically considers the resistance-
inducing effect of the treatment only on Neisseria gonorrhoeae. Antimicrobial resistance in …

The nonpathogenic commensal Neisseria: friends and foes in infectious disease

RB Dorey, AA Theodosiou, RC Read… - Current opinion in …, 2019 - journals.lww.com
Clinicians should have increased awareness of nonpathogenic Neisseria. First, as new
immunomodulating therapies become licenced, the interactions that maintain balance …

Rapid methicillin resistance diversification in Staphylococcus epidermidis colonizing human neonates

MS Datta, I Yelin, O Hochwald, I Kassis… - Nature …, 2021 - nature.com
Early in life, infants are colonized with multiple bacterial strains whose differences in gene
content can have important health consequences. Metagenomics-based approaches have …

Genetic, Functional, and Immunogenic Analyses of the O-Linked Protein Glycosylation System in Neisseria meningitidis Serogroup A ST-7 Isolates

LM Næss, IS Maugesten, DA Caugant… - Journal of …, 2023 - Am Soc Microbiol
Neisseria meningitidis exhibits a general O-linked protein glycosylation system in which pili
and other extracytoplasmic proteins are glycosylated. To investigate glycan antigenicity in …

Genomic epidemiology and population structure of Neisseria gonorrhoeae in Norway, 2016–2017

K Alfsnes, V Eldholm, AO Olsen… - Microbial …, 2020 - microbiologyresearch.org
This study presents the nationwide epidemiology of Neisseria gonorrhoeae, using whole-
genome sequencing of all culture-positive cases, which comprise roughly 40% of all cases …

Neisseria meningitidis and meningococcal disease: recent discoveries and innovations

RC Read - Current opinion in infectious diseases, 2019 - journals.lww.com
Meningococcal disease is well defined genomically for epidemiological purposes. There is
potential for unpredictable emergence of clones that may have reduced susceptibility even …