In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in
North Carolina were found to be contaminated with the industrial solvents trichloroethylene …

In people who are aged> 65 years, pharmacokinetics are influenced more by the loss of
kidney function than by the aging process of any other organ. A GFR of 30 to 60 ml/min …

The thousands of chemicals present in the environment (USGAO, 2013) must be triaged to
identify priority chemicals for human health risk research. Most chemicals have little of the …

The use of multi drug regimens among the elderly population has increased tremendously
over the last decade although the benefits of medications are always accompanied by …

A key element of risk assessment is accounting for the full range of variability in response to
environmental exposures. Default dose-response methods typically assume a 10-fold …

Introduction: The worldwide population is aging, and several age-associated physiological
and pathophysiological changes can affect drug disposition. This is particularly important in …

Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …

Domoic acid (DomA) is an excitatory amino acid which can accumulate in shellfish and
finfish under certain environmental conditions. DomA is a potent neurotoxin. In humans and …

Momentum is growing worldwide to use in vitro high-throughput screening (HTS) to evaluate
human health effects of chemicals. However, the integration of dosimetry into HTS assays …

Older adults are more likely to take more than two medications for medical conditions, and
polypharmacy is associated with increased risk of adverse events (fall injury, hyperkalemia …