Obesity, kidney dysfunction and hypertension: mechanistic links

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Nature reviews …, 2019 - nature.com
Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

中国高血压防治指南2010

刘力生 - 中华高血压杂志, 2011 - cqvip.com
2010 年中国高血压防治指南是在1999 年和2005 年版本基础上修订的, 由高血压联盟(中国)
和国家心血管病中心组织近百位专家, 包括心内科, 肾脏科, 神经科, 老年科和内分泌科等学科 …

Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Circulation …, 2015 - Am Heart Assoc
Excess weight gain, especially when associated with increased visceral adiposity, is a major
cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) …

Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of …

DE Kandzari, M Böhm, F Mahfoud, RR Townsend… - The Lancet, 2018 - thelancet.com
Background Previous catheter-based renal denervation studies have reported variable
efficacy results. We aimed to evaluate safety and blood pressure response after renal …

Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry

F Mahfoud, M Böhm, R Schmieder… - European Heart …, 2019 - academic.oup.com
Aims Several studies and registries have demonstrated sustained reductions in blood
pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in …

Mechanisms of diabetic complications

JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

The sympathetic nervous system alterations in human hypertension

G Grassi, A Mark, M Esler - Circulation research, 2015 - Am Heart Assoc
Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

The autonomic nervous system and hypertension

G Mancia, G Grassi - Circulation research, 2014 - Am Heart Assoc
Physiological studies have long documented the key role played by the autonomic nervous
system in modulating cardiovascular functions and in controlling blood pressure values …

Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy

PS Chen, LS Chen, MC Fishbein, SF Lin… - Circulation …, 2014 - Am Heart Assoc
Autonomic nervous system activation can induce significant and heterogeneous changes of
atrial electrophysiology and induce atrial tachyarrhythmias, including atrial tachycardia and …

The autonomic nervous system and heart failure

VG Florea, JN Cohn - Circulation research, 2014 - Am Heart Assoc
The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …