[HTML][HTML] Japanese encephalitis—the prospects for new treatments

L Turtle, T Solomon - Nature Reviews Neurology, 2018 - nature.com
Japanese encephalitis is a mosquito-borne disease that occurs in Asia and is caused by
Japanese encephalitis virus (JEV), a member of the genus Flavivirus. Although many …

Flaviviruses and the central nervous system: revisiting neuropathological concepts

OA Maximova, AG Pletnev - Annual review of virology, 2018 - annualreviews.org
Flaviviruses are major emerging human pathogens on a global scale. Some flaviviruses can
infect the central nervous system of the host and therefore are regarded as neurotropic. The …

A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

M Brecher, Z Li, B Liu, J Zhang, CA Koetzner… - PLoS …, 2017 - journals.plos.org
The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages
by host and viral proteases in order to produce the individual proteins that constitute an …

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

A Latanova, E Starodubova, V Karpov - Viruses, 2022 - mdpi.com
Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

Tinospora cordifolia Miers enhances the immune response in mice immunized with JEV-vaccine: A network pharmacology and experimental approach

P Tiwari, SA Ali, B Puri, A Kumar, AK Datusalia - Phytomedicine, 2023 - Elsevier
Abstract Background Tinospora cordifolia Miers.(TC)(Giloya/Guduchi) is a native Indian
herb, reported for its wide array of medicinal activities including immunomodulatory activity …

Inhibitors of tick-borne flavivirus reproduction from structure-based virtual screening

DI Osolodkin, LI Kozlovskaya, EV Dueva… - ACS Medicinal …, 2013 - ACS Publications
Flaviviruses form a large family of enveloped viruses affecting millions of people over the
world. To date, no specific therapy was suggested for the infected people, making the …

Basics of virology

PE Pellett, S Mitra, TC Holland - Handbook of clinical neurology, 2014 - Elsevier
Viruses are important pathogens of the nervous system. Here we describe the basic
properties of viruses and the principles of virus classification, evolution, structure, and …

Mapping the spatial distribution of the Japanese encephalitis vector, Culex tritaeniorhynchus Giles, 1901 (Diptera: Culicidae) within areas of Japanese encephalitis …

J Longbottom, AJ Browne, DM Pigott, ME Sinka… - Parasites & vectors, 2017 - Springer
Background Japanese encephalitis (JE) is one of the most significant aetiological agents of
viral encephalitis in Asia. This medically important arbovirus is primarily spread from …

[PDF][PDF] How viruses infiltrate the central nervous system

A Michalicova, K Bhide, M Bhide, A Kovac - Acta Virol, 2017 - researchgate.net
Central nervous system is protected by the blood-brain barrier, which represents a physical,
metabolic and transport barrier and is considered to be a part of a highly dynamic system …

Predictors, neuroimaging characteristics and long-term outcome of severe European tick-borne encephalitis: a prospective cohort study

T Lenhard, D Ott, NJ Jakob, M Pham, P Bäumer… - PloS one, 2016 - journals.plos.org
Background and Objectives Tick-borne encephalitis (TBE) still represents a considerable
medical and health economic problem in Europe and entails a potential threat to travellers …