Hydrogels for RNA delivery
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …
genetic level, and some have been approved for clinical use, including the recent COVID-19 …
MicroRNAs as therapeutic targets in cardiovascular disease
B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction
J Yuan, H Yang, C Liu, L Shao, H Zhang… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
The potential role of miRNAs in the pathogenesis of cardiovascular diseases–A focus on signaling pathways interplay
EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …
to posttranscriptional regulation of gene expression in critical cardiac physiological and …
[HTML][HTML] Biomaterials to enhance stem cell transplantation
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …
medicine approaches and open promising avenues to repair, replace, and regenerate …
Acceptor engineering for optimized ROS generation facilitates reprogramming macrophages to M1 phenotype in photodynamic immunotherapy
Reprogramming tumor‐associated macrophages to an antitumor M1 phenotype by
photodynamic therapy is a promising strategy to overcome the immunosuppression of tumor …
photodynamic therapy is a promising strategy to overcome the immunosuppression of tumor …
Advances in injectable hydrogel strategies for heart failure treatment
Heart failure (HF) affects 60 million people worldwide and has developed into a global
public health problem surpassing cancer and urgently needs to be solved. According to the …
public health problem surpassing cancer and urgently needs to be solved. According to the …
MicroRNAs in cardiac diseases
RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …
regulation of gene expression in major cardiac physiological and pathological processes …
A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo
J Ding, Y Yao, J Li, Y Duan, JR Nakkala, X Feng… - Small, 2020 - Wiley Online Library
The excessive reactive oxygen species (ROS) and hypoxia deteriorate the inflammation‐
related diseases such as myocardial infarction (MI), and thereby deter the normal tissue …
related diseases such as myocardial infarction (MI), and thereby deter the normal tissue …