Hydrogels for RNA delivery

R Zhong, S Talebian, BB Mendes, G Wallace… - Nature materials, 2023 - nature.com
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

S Mirzaei, MH Gholami, F Hashemi, A Zabolian… - Drug Discovery …, 2022 - Elsevier
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …

Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction

J Yuan, H Yang, C Liu, L Shao, H Zhang… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …

The potential role of miRNAs in the pathogenesis of cardiovascular diseases–A focus on signaling pathways interplay

EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

[HTML][HTML] Biomaterials to enhance stem cell transplantation

BN Kharbikar, P Mohindra, TA Desai - Cell Stem Cell, 2022 - cell.com
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

Acceptor engineering for optimized ROS generation facilitates reprogramming macrophages to M1 phenotype in photodynamic immunotherapy

G Yang, JS Ni, Y Li, M Zha, Y Tu… - Angewandte Chemie …, 2021 - Wiley Online Library
Reprogramming tumor‐associated macrophages to an antitumor M1 phenotype by
photodynamic therapy is a promising strategy to overcome the immunosuppression of tumor …

Advances in injectable hydrogel strategies for heart failure treatment

S He, Z Zhang, R Luo, Q Jiang, L Yang… - Advanced Healthcare …, 2023 - Wiley Online Library
Heart failure (HF) affects 60 million people worldwide and has developed into a global
public health problem surpassing cancer and urgently needs to be solved. According to the …

MicroRNAs in cardiac diseases

RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

A Reactive Oxygen Species Scavenging and O2 Generating Injectable Hydrogel for Myocardial Infarction Treatment In vivo

J Ding, Y Yao, J Li, Y Duan, JR Nakkala, X Feng… - Small, 2020 - Wiley Online Library
The excessive reactive oxygen species (ROS) and hypoxia deteriorate the inflammation‐
related diseases such as myocardial infarction (MI), and thereby deter the normal tissue …