Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for
personalized medicine. In the last decade, major chemical developments and improvements …

Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …

Liraglutide, an anti-diabetic drug and agonist of the glucagon-like peptide one receptor
(GLP1R), has recently been approved to treat obesity in individuals with or without type 2 …

The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and
integrate hormonal status with environmental cues to ensure reproductive success. Here we …

Early-life determinants are thought to be a major factor in the rapid increase of obesity.
However, while maternal nutrition has been extensively studied, the effects of breastfeeding …