Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …

Post-translational modifications (PTMs) are chemical modifications that can regulate the
activity and function of proteins. From an evolutionary perspective, they also represent a fast …

Phosphorylation is a major regulatory mechanism controlling protein and cell function.
Phosphoproteomics is continuing to reveal the extent and complexity of protein …

Abstract Cyclin‐dependent kinases (CDKs), the master regulators of cell division, are
activated by different cyclins at different cell cycle stages. In addition to being activators of …

The complexity of multisite phosphorylation mechanisms in regulating nuclear localization
signals (NLSs) and nuclear export signals (NESs) is not understood, and its potential has …

A near-constant feature of stress responses is a downregulation or arrest of the cell cycle,
resulting in transient growth slowdown. To investigate the role of growth slowdown in the …

The cell cycle is the essential biological process where one cell replicates its genome and
segregates the resulting two copies into the daughter cells during mitosis. Several aspects of …

Simple Summary The kinetics of Cyclin Dependent Kinase 1 (CDK1) activation must be
strictly controlled to guarantee a timely and physiological entry into mitosis. CDC6, a known …

Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-
dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae …

Most biological processes are regulated by signaling modules that bind to short linear
motifs. For protein kinases, substrates may have full or only partial matches to the kinase …