The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for
refractory B cell malignancies, especially acute lymphoblastic leukemia (ALL) 1. Although a …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Summary Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function
activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and …

Ethical considerations constrain the in vivo study of human hemopoietic stem cells (HSC).
To overcome this limitation, small animal models of human HSC engraftment have been …

▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes
mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death …

Premature Ovarian Failure and Ovarian Autoimmunity* | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search …

Type 2 diabetes is a result of chronic insulin resistance and loss of functional pancreatic β-
cell mass. Strategies to preserve β-cell mass and a greater understanding of the …