Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has
been linked to various diseases. Autophagy is a membrane driven process and tightly …

The retinal pigment epithelium (RPE) is a highly specialized monolayer of polarized,
pigmented epithelial cells that resides between the vessels of the choriocapillaris and the …

The glycolytic enzyme, pyruvate kinase Pyk1 maintains telomere heterochromatin by
phosphorylating histone H3T11 (H3pT11), which promotes SIR (silent information regulator) …

As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …

General autophagy is an evolutionarily conserved process in eukaryotes, by which
intracellular materials are transported into and degraded inside lysosomes or vacuoles, with …

Autophagy is a critical process to maintain homeostasis, differentiation, and development.
How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we …

The Cdk8 kinase module (CKM), a conserved, detachable unit of the Mediator complex,
plays a vital role in regulating transcription and communicating stress signals from the …

Background Autophagy is a catabolic process for degradation of intracellular components.
Damaged proteins and organelles are engulfed in double-membrane vesicles ultimately …

Yeast biomass has untapped potential as a sustainable source of nutritional protein. To
realise this, current production capacity and the demand for yeast-based products in food …

Autophagy is a key lysosomal degradative mechanism allowing a prosurvival response to
stresses, especially nutrient starvation. Here we investigate the mechanism of autophagy …