The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Extracellular solute-binding proteins of bacteria serve as chemoreceptors, recognition
constituents of transport systems, and initiators of signal transduction pathways. Over 50 …

Receptors for the major excitatory neurotransmitter glutamate include metabotropic (C
protein-coupled) and ionotropic fglutamate-gated ion channel) types. These receptors have …

The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with
other members of the G protein-coupled receptor family and exhibit several distinctive …

Activation of the NMDA subtype of ionotropic glutamate receptors requires binding of both L-
glutamate and the coagonist glycine. Site-directed mutagenesis of the NMDARI (NRl) …

We have molecularly cloned a calcium sensing receptor (CaSR) from a rat striatal cDNA
library. Rat CaSR displays 92% overall homology to its bovine counterpart with seven …

Calcium ions are essential for a wide variety of biologic functions, including vital
extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity …

Eukaryotic multidrug resistance protein (HDR) and cystic fibrosis transmembrane regulator
(CFTR) belong to the family of traffic ATPases and possess channel-like activity to allow the …

Two discontinuous segments (S1 and S2), separated by membrane‐associated domains, in
ionotropic glutamate receptor (GluR) subunits show sequence similarity to bacterial …

The first crystal structure of the iron-transporter ferric ion-binding protein from Haemophilus
influenzae (hFBP), at 1.6 Å resolution, reveals the structural basis for iron uptake and …