Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …

Embryonic metanephroi, differentiating into the adult kidney, have come to be a generally
accepted model system for organogenesis. Nephrogenesis implies a highly controlled …

Autosomal dominant polycystic kidney disease (ADPKD) is a common human genetic
disease characterized by cyst formation in kidney tubules and other ductular epithelia. Cells …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Integrins are heterodimeric cell surface receptors that mediate heterophilic cell-cell
interactions and interactions between cells and the extracellular matrix (Hynes RO. Cell 69 …

Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is
characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of …

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Cystic and bright kidneys can pose a significant diagnostic dilemma when discovered as an
incidental finding at the time of a routine fetal ultrasound scan. There are diverse aetiologies …

Polycystic kidney disease (PKD) is a diverse group of human monogenic lethal conditions
inherited as autosomal dominant (AD) or recessive (AR) traits. Recent development of …