Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical
imaging techniques for observations through biological tissue, allows 3-D quantitative …

Significance: Measurement and imaging of hemoglobin oxygenation are used extensively in
the detection and diagnosis of disease; however, the applied instruments vary widely in their …

The prevalence of diabetes complications is a significant public health problem with a
considerable economic cost. Thus, the timely diagnosis of complications and prevention of …

Monitoring the blood supply in the lower extremities is critical for individuals who are
vulnerable to vascular dysfunction. Current clinical approaches are ineffective in observing …

BACKGROUND: Objective, reliable and easy screening for peripheral artery disease (PAD)
is essential to confirm the diagnosis and initiate the respective treatment. Therefore, a new …

The microvasculature serves an imperative function in regulating perfusion and nutrient
exchange throughout the body, adaptively altering blood flow to preserve hemodynamic and …

We report on the design and first in vivo tests of a novel non-contact scanning imaging
system for time-domain near-infrared spectroscopy. Our system is based on a null source …

Objective Vascular optical tomographic imaging (VOTI) is a novel imaging modality that is
capable of detecting hemoglobin concentrations in tissue. VOTI is non-invasive, non …

Diagnosis of articular cartilage pathology in the early disease stages using current clinical
diagnostic imaging modalities is challenging, particularly because there is often no visible …

Based on recent developments in both single-photon detectors and timing electronic circuits,
we designed a compact and cost effective time-domain diffuse optical tomography system …