The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common
underlying events in neurodegeneration. This pathogenic “triad” characterizes the …

Febrile infection‐related epilepsy syndrome (FIRES) is a rare catastrophic epileptic
encephalopathy that presents suddenly in otherwise normal children and young adults …

Increasing evidence supports a pathogenic role of unabated neuroinflammation in various
central nervous system (CNS) diseases, including epilepsy. Neuroinflammation is not a …

Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying
mechanisms of the disease (epileptogenesis). There are no treatments for preventing …

Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such …

Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …