Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Z Chen, L Zhou, L Liu, Y Hou, M Xiong, Y Yang… - Nature …, 2020 - nature.com
Although substantial progress has been made in cancer biology and treatment, clinical
outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor …

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

SV Lindskrog, F Prip, P Lamy, A Taber… - Nature …, 2021 - nature.com
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …

Tumour microenvironment as a predictive factor for immunotherapy in non-muscle-invasive bladder cancer

A Semeniuk-Wojtaś, K Poddębniak-Strama… - Cancer Immunology …, 2023 - Springer
Bladder cancer (BC) can be divided into two subgroups depending on invasion of the
muscular layer: non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder …

Molecular oncology of bladder cancer from inception to modern perspective

SD Lokeshwar, M Lopez, S Sarcan, K Aguilar… - Cancers, 2022 - mdpi.com
Simple Summary Bladder cancer (BC) is a common cancer that causes high morbidity and
mortality among affected patients. As a carcinogen-driven cancer, molecular oncology of BC …

Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer

SA Plumber, T Tate, H Al-Ahmadie, X Chen… - Nature …, 2024 - nature.com
Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-
basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable …

Development of an immune-related risk signature for predicting prognosis in lung squamous cell carcinoma

D Fu, B Zhang, L Yang, S Huang, W Xin - Frontiers in Genetics, 2020 - frontiersin.org
Lung squamous cell carcinoma (LSCC) is the most common subtype of non-small cell lung
cancer. Immunotherapy has become an effective treatment in recent years, while patients …

Novel genetic subtypes of urothelial carcinoma with differential outcomes on immune checkpoint blockade

M Sarfaty, M Golkaram, SA Funt… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Immune checkpoint blockade (ICB) therapy has significantly improved clinical
outcomes in bladder cancer. Identification of correlates of benefit is critical to select …

Role of NRP1 in bladder cancer pathogenesis and progression

Y Dong, W Ma, Z Shi, Z Zhang, J Zhou, Y Li… - Frontiers in …, 2021 - frontiersin.org
Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common
malignancy of the urinary system. In the current study, we investigated the function and …

Pathological and survival outcomes associated with variant histology bladder cancers managed by cystectomy with or without neoadjuvant chemotherapy

A Hajiran, M Azizi, AM Aydin, L Zemp… - The Journal of …, 2021 - auajournals.org
Purpose: Although neoadjuvant chemotherapy is associated with a survival advantage in
pure urothelial, muscle invasive bladder cancer, the role of neoadjuvant chemotherapy is …

Molecular biomarkers of progression in non-muscle-invasive bladder cancer—beyond conventional risk stratification

M Olislagers, FC de Jong, VC Rutten… - Nature Reviews …, 2024 - nature.com
The global incidence of bladder cancer is more than half a million diagnoses each year.
Bladder cancer can be categorized into non-muscle-invasive bladder cancer (NMIBC) …